Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake

F P Bymaster; E E Beedle; J Findlay; P T Gallagher; J H Krushinski; S Mitchell; D W Robertson; D C Thompson; L Wallace; D T Wong

doi:10.1016/j.bmcl.2003.08.079

Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4477-80. doi: 10.1016/j.bmcl.2003.08.079.

Authors

F P Bymaster¹, E E Beedle, J Findlay, P T Gallagher, J H Krushinski, S Mitchell, D W Robertson, D C Thompson, L Wallace, D T Wong

Affiliation

¹ Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

PMID: 14643350
DOI: 10.1016/j.bmcl.2003.08.079

Abstract

A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for the treatment of depression.

MeSH terms

Antidepressive Agents / chemical synthesis
Antidepressive Agents / therapeutic use
Binding Sites
Clinical Trials as Topic
Depressive Disorder / drug therapy
Duloxetine Hydrochloride
Humans
Kinetics
Norepinephrine / antagonists & inhibitors*
Selective Serotonin Reuptake Inhibitors / chemical synthesis
Selective Serotonin Reuptake Inhibitors / chemistry*
Selective Serotonin Reuptake Inhibitors / pharmacology
Structure-Activity Relationship
Thiophenes / chemistry*
Thiophenes / therapeutic use

Substances

Antidepressive Agents
Serotonin Uptake Inhibitors
Thiophenes
Duloxetine Hydrochloride
Norepinephrine